Formulation development and evaluation of lamivudine controlled release tablets using cross-linked sago starch

Singh, Akhilesh Vikram and Nath, Lila Kanta (2013) Formulation development and evaluation of lamivudine controlled release tablets using cross-linked sago starch. In: EXPERT OPINION ON DRUG DELIVERY, 10 (2). pp. 173-182.

PDF exp_opi_dru_del_10-2_173_2013.pdf - Published Version Restricted to Registered users only Download (594kB) | Request a copy

Abstract

Objectives: Modified starches based polymeric substances find utmost applicability in pharmaceutical formulation development. Cross-linked starches showed very promising results in drug delivery application. The present investigation concerns with the development of controlled release tablets of lamivudine using cross-linked sago starch. Methods: The cross-linked derivative was synthesized with phosphorous oxychloride and native sago starch in basic pH medium. The cross-linked sago starch was tested for acute toxicity and drug-excipient compatibility study. The formulated tablets were evaluated for various physical characteristics, in vitro dissolution release study and in vivo pharmacokinetic study in rabbit model. Results: In vitro release study showed that the optimized formulation exhibited highest correlation (R) in case of zero order kinetic model and the release mechanism followed a combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (T-max, C-max, AUC, V-d, T-1/2, and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir (R). Conclusion: The cross-linked starch showed promising results in terms of controlling the release behavior of the active drug from the matrix. The hydrophilic matrix synthesized by cross-linking could be used with a variety of active pharmaceutical ingredients for making their controlled/sustained release formulations.

Item Type:	Journal Article
Publication:	EXPERT OPINION ON DRUG DELIVERY
Publisher:	INFORMA HEALTHCARE
Additional Information:	Copyright for this article belongs to INFORMA HEALTHCARE, ENGLAND
Keywords:	controlled release;cross-linked starch;lamivudine;pharmacokinetic
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	18 Feb 2013 09:02
Last Modified:	19 Feb 2013 05:03
URI:	http://eprints.iisc.ac.in/id/eprint/45811

Actions (login required)

View Item