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Caryophyllene-Rich Essential Oil of Didymocarpus tomentosa: Chemical Composition and Cytotoxic Activity

Gowda, Prameela Javarayi and Ramakrishnaiah, Hanumanthaiah and Krishna, Venkatarangaiah and Narra, Sivakrishna and Jagannath, Nataraj (2012) Caryophyllene-Rich Essential Oil of Didymocarpus tomentosa: Chemical Composition and Cytotoxic Activity. In: NATURAL PRODUCT COMMUNICATIONS, 7 (11). pp. 1535-1538.

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The essential oil from the leaves of Didymocarpus tomentosa was extracted by hydrodistillation and analyzed by GC/FID and GC/MS. Twenty five constituents amounting to 81.6% of the oil were identified. The leaf oil contained 78.7% sesquiterpenes and 2.9% monoterpenes. The leaf essential oil of D. tomentosa is a unique caryophyllene-rich natural source containing beta-caryophyllene, caryophyllene oxide, alpha-humulene and humulene oxide. The cytotoxic activity of the oil was determined by the BSLT using shrimp larva and the MTT assay using HeLa tumor cell line. The oil showed significant cytotoxic activity with LC50 and IC50 values of 12.26 and 11.4 mu g/mL, respectively. This is the first report on the chemical composition and cytotoxic activity of the essential oil of D. tomentosa.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to NATURAL PRODUCTS INC, WESTERVILLE, USA
Keywords: Didymocarpus tomentosa;Essential oil;GC/FID; GC/MS;Sesquiterpenes;beta-Caryophyllene;Cytotoxic activity
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 02 Jan 2013 07:55
Last Modified: 02 Jan 2013 07:56
URI: http://eprints.iisc.ac.in/id/eprint/45593

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