Synthesis, characterization and pharmacological study of 4,5-dihydropyrazolines carrying pyrimidine moiety

Adhikari, Adithya and Kalluraya, Balakrishna and Sujith, Kizhakke Veedu and Gouthamchandra, Kuluvar and Jairam, Ravikumar and Mahmood, Riaz and Sankolli, Ravish (2012) Synthesis, characterization and pharmacological study of 4,5-dihydropyrazolines carrying pyrimidine moiety. In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 55 . pp. 467-474.

PDF eur_jol_med_che_55_467_2012.pdf - Published Version Restricted to Registered users only Download (595kB) | Request a copy

Abstract

A series of 5-bromo-2-(3,5-diaryl-4,5-dihydro-1H-Pyrazol-1-yl)pyrimidine were prepared under conventional heating as well as microwave reaction condition. The newly synthesized compounds were characterized on the basis of elemental, spectral and single crystal X-ray studies. These new compounds were screened for their antioxidant, anti-inflammatory and analgesic activities. Some of these compounds exhibited potent biological activities compared to the standard drug. (C) 2012 Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Publication:	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Publisher:	Elsevier Science
Additional Information:	Copyright for this article belongs to Elsevier Science, FRANCE
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	13 Dec 2012 05:31
Last Modified:	13 Dec 2012 05:31
URI:	http://eprints.iisc.ac.in/id/eprint/45503

Actions (login required)

View Item