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Development of micro-shock wave assisted dry particle and fluid jet delivery system

Rakesh, SG and Gnanadhas, Divya Prakash and Allam, Uday Sankar and Nataraja, Karaba N and Barhai, PK and Jagadeesh, Gopalan and Chakravortty, Dipshikha (2012) Development of micro-shock wave assisted dry particle and fluid jet delivery system. In: Applied Microbiology and Biotechnology, 96 (3). pp. 647-662.

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Official URL: http://dx.doi.org/10.1007/s00253-012-4196-8


Small quantity of energetic material coated on the inner wall of a polymer tube is proposed as a new method to generate micro-shock waves in the laboratory. These micro-shock waves have been harnessed to develop a novel method of delivering dry particle and liquid jet into the target. We have generated micro-shock waves with the help of reactive explosive compound high melting explosive (octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine) and traces of aluminium] coated polymer tube, utilising 9 J of energy. The detonation process is initiated electrically from one end of the tube, while the micro-shock wave followed by the products of detonation escape from the open end of the polymer tube. The energy available at the open end of the polymer tube is used to accelerate tungsten micro-particles coated on the other side of the diaphragm or force a liquid jet out of a small cavity filled with the liquid. The micro-particles deposited on a thin metal diaphragm (typically 100-mu m thick) were accelerated to high velocity using micro-shock waves to penetrate the target. Tungsten particles of 0.7 mu m diameter have been successfully delivered into agarose gel targets of various strengths (0.6-1.0 %). The device has been tested by delivering micro-particles into potato tuber and Arachis hypogaea Linnaeus (ground nut) stem tissue. Along similar lines, liquid jets of diameter 200-250 mu m (methylene blue, water and oils) have been successfully delivered into agarose gel targets of various strengths. Successful vaccination against murine salmonellosis was demonstrated as a biological application of this device. The penetration depths achieved in the experimental targets are very encouraging to develop a future device for biological and biomedical applications.

Item Type: Journal Article
Publication: Applied Microbiology and Biotechnology
Publisher: Springer
Additional Information: Copyright of this article belongs to Springer.
Keywords: Shock Wave; Micro-Shock Wave; Liquid Jet Delivery System; Needle-Less Vaccination; Dry Particle Delivery System
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Mechanical Sciences > Aerospace Engineering(Formerly Aeronautical Engineering)
Date Deposited: 19 Feb 2013 05:20
Last Modified: 19 Feb 2013 05:20
URI: http://eprints.iisc.ac.in/id/eprint/45372

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