Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities

Thomas, Sajesh P and Nagarajan, K and Row, Guru TN (2012) Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities. In: CHEMICAL COMMUNICATIONS, 48 (85). pp. 10559-10561.

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Abstract

Crystal structures of polymorphs and solvatomorphs of the potential anxiolytic drug fenobam exhibit an exclusive preference for one of the two possible tautomeric structures. A novel methodology based on nonlinear optical response has been successfully employed to detect the presence of a polymorphic impurity in a mixture of polymorphs.

Item Type:	Journal Article
Publication:	CHEMICAL COMMUNICATIONS
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	Copyright for this article belongs to ROYAL SOC CHEMISTRY
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	09 Nov 2012 12:09
Last Modified:	09 Nov 2012 12:11
URI:	http://eprints.iisc.ac.in/id/eprint/45331

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