A study of epileptogenic network structures in rat hippocampal cultures using first spike latencies during synchronization events

Raghavan, Mohan and Amrutur, Bharadwaj and Srinivas, Kalyan V and Sikdar, SujitK (2012) A study of epileptogenic network structures in rat hippocampal cultures using first spike latencies during synchronization events. In: PHYSICAL BIOLOGY, 9 (5).

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Abstract

Study of hypersynchronous activity is of prime importance for combating epilepsy. Studies on network structure typically reconstruct the network by measuring various aspects of the interaction between neurons and subsequently measure the properties of the reconstructed network. In sub-sampled networks such methods lead to significant errors in reconstruction. Using rat hippocampal neurons cultured on a multi-electrode array dish and a glutamate injury model of epilepsy in vitro, we studied synchronous activity in neuronal networks. Using the first spike latencies in various neurons during a network burst, we extract various recurring spatio-temporal onset patterns in the networks. Comparing the patterns seen in control and injured networks, we observe that injured networks express a wide diversity in their foci (origin) and activation pattern, while control networks show limited diversity. Furthermore, we note that onset patterns in glutamate injured networks show a positive correlation between synchronization delay and physical distance between neurons, while control networks do not.

Item Type:	Journal Article
Publication:	PHYSICAL BIOLOGY
Publisher:	IOP PUBLISHING LTD
Additional Information:	Copyright for this article belongs to IOP PUBLISHING LTD, ENGLAND
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit Division of Electrical Sciences > Electrical Communication Engineering
Date Deposited:	06 Dec 2012 10:22
Last Modified:	06 Dec 2012 10:22
URI:	http://eprints.iisc.ac.in/id/eprint/45317

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