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Mixture solubilities of nitrobenzoic acid isomers in supercritical carbon dioxide

Reddy, Sivamohan N and Madras, Giridhar (2012) Mixture solubilities of nitrobenzoic acid isomers in supercritical carbon dioxide. In: JOURNAL OF SUPERCRITICAL FLUIDS, 70 . pp. 66-74.

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Official URL: http://dx.doi.org/10.1016/j.supflu.2012.06.012


The ternary solubilities of solid isomers of nitrobenzoic acid (NBA) were experimentally determined at 308, 318 and 328K over a pressure range of 12-18 MPa in supercritical carbon dioxide (SCCO2). Compared to its binary solubility, the ternary solubilities of m-NBA increased at 308 K while it decreased at 328 K. However, the ternary solubilities of p-NBA increased at all temperatures and pressures except at 13 MPa and 328K. A new model was developed by applying solution model and activity coefficient model for the ternary solubilities of pharmaceutical and non-pharmaceutical solid mixtures in terms of temperature, density and cosolute composition. The model equation involves four temperature independent constraint-free parameters. The model equation correlates the ternary solubilities of seven pharmaceutical solid mixtures along with current data with an average AARD around 9.5% and sixteen non-pharmaceutical solid mixtures with 9% AARD. (C) 2012 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to ELSEVIER SCIENCE BV
Keywords: Ternary solubilities; Nitrobenzoic acid isomers; Cosolute composition; Solution model; Activity coefficient model; Pharmaceutical solid mixtures
Department/Centre: Division of Mechanical Sciences > Chemical Engineering
Date Deposited: 08 Jan 2013 12:29
Last Modified: 08 Jan 2013 12:29
URI: http://eprints.iisc.ac.in/id/eprint/45259

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