Conformational Polymorphism in a Non-steroidal Anti-inflammatory Drug, Mefenamic Acid

SeethaLekshmi, Sunil and Row, Tayur Guru N (2012) Conformational Polymorphism in a Non-steroidal Anti-inflammatory Drug, Mefenamic Acid. In: CRYSTAL GROWTH & DESIGN, 12 (8). pp. 4283-4289.

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Abstract

For several years, the non-steroidal anti-inflammatory drug mefenamic acid, MA, has been known to exist as dimorphs (I and II). We report a new metastable polymorph (III) of MA obtained during attempted co-crystallization experiments and establish its stability relationship with existing forms. At elevated temperatures I and III convert to II, as evident from DSC experiments. On the basis of the lattice energy calculations in conjunction with thermal analysis, the stability order is proposed to be I > II > III at ambient conditions, whereas at elevated temperature the order is II > I > III. In either condition III is a metastable form and hence transforms to I at ambient conditions and to II at higher temperatures. Also we report the structural studies of a DMF solvate and a cytosine complex.

Item Type:	Journal Article
Publication:	CRYSTAL GROWTH & DESIGN
Publisher:	AMER CHEMICAL SOC
Additional Information:	Copyright for this article belongs to AMER CHEMICAL SOC
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	12 Dec 2012 07:03
Last Modified:	12 Dec 2012 07:03
URI:	http://eprints.iisc.ac.in/id/eprint/45236

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