Synthesis, antimicrobial and cytotoxic activities of sulfone linked bis heterocycles

Muralikrishna, A and Venkatesh, BC and Padmavathi, V and Padmaja, A and Kondaiah, P and Krishna, Siva N (2012) Synthesis, antimicrobial and cytotoxic activities of sulfone linked bis heterocycles. In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 54 . pp. 605-614.

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Abstract

A new class of sulfone linked bis heterocycles viz., pyrrolyl/pyrazolyl arylaminosulfonylmethyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, and 1,2,4-triazoles were prepared and tested for antimicrobial activity and cytotoxicity. The chloro-substituted compounds 5c, 8c and 14c showed comparable antibacterial activity to chloramphenicol against Pseudomonasaeruginosa and compound 5c exhibited comparable antifungal activity to ketoconazole against Penicilliumchrysogenum. One of the compounds, vinylsulfonyl oxadiazole showed appreciably cytotoxic activity on A549 lung carcinoma cells with an IC50 at a concentration of 31.7 mu M. (C) 2012 Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Publication:	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Publisher:	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Additional Information:	Copyright for this article belongs to Elsevier Science
Keywords:	Pyrroles;Pyrazoles;Oxadiazoles;Thiadiazoles;Triazoles; 1,3-Dipolar cycloaddition;Antimicrobial activity;Cytotoxicity
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	12 Dec 2012 07:59
Last Modified:	12 Dec 2012 07:59
URI:	http://eprints.iisc.ac.in/id/eprint/45175

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