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The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis

Arshad, Najla and Visweswariah, Sandhya S (2012) The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis. In: FEBS Letters, 586 (18, SI). pp. 2835-2840.

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Official URL: http://dx.doi.org/10.1016/j.febslet.2012.07.028


Guanylyl cyclase C (GC-C) is predominantly expressed in intestinal epithelial cells and serves as the receptor for the gastrointestinal hormones guanylin and uroguanylin, and the heat-stable enterotoxin, the causative agent for Travellers' Diarrhea. Activation of GC-C results in an increase in intracellular levels of cGMP, which can regulate fluid and ion secretion, colon cell proliferation, and the gut immune system. This review highlights recent findings arising from studies in the GC-C knockout mouse, along with enigmatic results obtained from the first descriptions of human disease caused by mutations in the GC-C gene. We provide some insight into these new findings and comment on areas of future study, which may enhance our knowledge of this evolutionarily conserved receptor and signaling system. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

Item Type: Journal Article
Publication: FEBS Letters
Publisher: Elsevier Science
Additional Information: Copyright for this article is belongs to Elsevier Science.
Keywords: Guanylyl cyclase C;cGMP;Intestine
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 23 Nov 2012 06:16
Last Modified: 23 Nov 2012 06:16
URI: http://eprints.iisc.ac.in/id/eprint/45140

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