Sm(III)nitrate-catalyzed one-pot synthesis of furano3,2c]-1,2,3,4-tetrahydroquinolines and DNA photocleavage studies

Bindu, PJ and Mahadevan, KM and Naik, Ravikumar TR (2012) Sm(III)nitrate-catalyzed one-pot synthesis of furano3,2c]-1,2,3,4-tetrahydroquinolines and DNA photocleavage studies. In: JOURNAL OF MOLECULAR STRUCTURE, 1020 . pp. 142-147.

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Abstract

The synthesis and DNA photocleavage studies of furano3,2-c]-1,2,3,4-tetrahydroquinolines have been reported. Sm(III)nitrate was found to be an efficient for the Diels-Alder reaction of aryl amines with 2,3-dihydrofuran to offer the corresponding furano3,2-c]-1,2,3,4-tetrahydroquinolines derivatives as a mixture of cis/trans stereoisomers in moderate yields. The aqueous solubility of acid catalyst can be recycled without significant loss of activity. The DNA photocleavage studies shows that, the cis/trans stereoisomers are good DNA cleavage mimic in terms of molecular structure. (C) 2012 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Publication:	JOURNAL OF MOLECULAR STRUCTURE
Publisher:	ELSEVIER SCIENCE BV
Additional Information:	Copyright for this article belongs to Elsevier
Keywords:	Sm(III)nitrate; Furano3,2-c]-1,2,3,4-tetrahydroquinolines; DNA; Photocleavage
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	08 Aug 2012 08:41
Last Modified:	08 Aug 2012 08:41
URI:	http://eprints.iisc.ac.in/id/eprint/44910

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