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IgG2 subclass isotype antibody and intrauterine infections

Syal, Kirtimaan and Karande, Anjali A (2012) IgG2 subclass isotype antibody and intrauterine infections. In: CURRENT SCIENCE, 102 (11). pp. 1534-1538.

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Official URL: http://www.currentscience.ac.in/Volumes/102/11/153...


The foetus is dependent on its mother for passive immunity involving receptor-mediated specific transport of antibodies. IgG antibody is present in highest concentration in serum and is the only antibody type that can cross the placenta efficiently, except for its IgG2 subclass. Most of the pathogenic manifestations affecting the foetus involve capsular antigens and polysaccharides of pathogens and it is known that immune response to these antigens is primed to the predominant production of IgG2 type of antibody. Paradoxically, the IgG2 subclass cannot cross the placenta and neutralize such antigens; therefore, infections related to these antigens may persist and can lead to serious conditions like miscarriage and stillbirth. This article describes in brief the properties of IgG subclasses, intrauterine infections seen during pregnancy and discusses possible IgG-based strategies to manage infections to afford protection to the foetus.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the Indian Academy of Sciences
Keywords: Class switching; clinical approaches; foetal immunity; IgG subclasses; intrauterine infections
Department/Centre: Division of Biological Sciences > Biochemistry
Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 30 Jul 2012 05:00
Last Modified: 30 Jul 2012 05:00
URI: http://eprints.iisc.ac.in/id/eprint/44861

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