# Linearization and Reconstruction of Non-linear Diffuse Optical Tomographic Image

Biswas, SK and Rajan, K and Vasu, RM (2012) Linearization and Reconstruction of Non-linear Diffuse Optical Tomographic Image. In: Conference on Medical Imaging - Physics of Medical Imaging, FEB 05-08, 2012 , San Diego, CA, USA.

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Official URL: http://dx.doi.org/10.1117/12.911182

## Abstract

Diffuse optical tomography (DOT) is one of the ways to probe highly scattering media such as tissue using low-energy near infra-red light (NIR) to reconstruct a map of the optical property distribution. The interaction of the photons in biological tissue is a non-linear process and the phton transport through the tissue is modelled using diffusion theory. The inversion problem is often solved through iterative methods based on nonlinear optimization for the minimization of a data-model misfit function. The solution of the non-linear problem can be improved by modeling and optimizing the cost functional. The cost functional is f(x) = x(T)Ax - b(T)x + c and after minimization, the cost functional reduces to Ax = b. The spatial distribution of optical parameter can be obtained by solving the above equation iteratively for x. As the problem is non-linear, ill-posed and ill-conditioned, there will be an error or correction term for x at each iteration. A linearization strategy is proposed for the solution of the nonlinear ill-posed inverse problem by linear combination of system matrix and error in solution. By propagating the error (e) information (obtained from previous iteration) to the minimization function f(x), we can rewrite the minimization function as f(x; e) = (x + e)(T) A(x + e) - b(T)(x + e) + c. The revised cost functional is f(x; e) = f(x) + e(T)Ae. The self guided spatial weighted prior (e(T)Ae) error (e, error in estimating x) information along the principal nodes facilitates a well resolved dominant solution over the region of interest. The local minimization reduces the spreading of inclusion and removes the side lobes, thereby improving the contrast, localization and resolution of reconstructed image which has not been possible with conventional linear and regularization algorithm.

Item Type: Conference Proceedings Proceedings of SPIE SPIE-INT SOC OPTICAL ENGINEERING Division of Physical & Mathematical Sciences > Instrumentation Appiled PhysicsDivision of Physical & Mathematical Sciences > Physics 24 Jul 2012 12:53 24 Jul 2012 12:53 http://eprints.iisc.ac.in/id/eprint/44845