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Regioselective synthesis and antimicrobial studies of ester linked 1,4-disubstituted 1,2,3-bistriazoles

Lal, Kashmiri and Kumar, Ashwani and Pavan, M S and Kaushik, C P (2012) Regioselective synthesis and antimicrobial studies of ester linked 1,4-disubstituted 1,2,3-bistriazoles. In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22 (13). pp. 4353-4357.

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Official URL: http://dx.doi.org/10.1016/j.bmcl.2012.05.008


A series of 1,4-disubstituted 1,2,3-bistriazoles was synthesized via click chemistry by cycloaddition of various bisalkynes with benzyl/2-phenylethyl azide. Synthesized triazoles were characterized by IR, H-1 NMR, C-13 NMR and mass spectral techniques. All the compounds were evaluated for antibacterial/antifungal activities and found to possess moderate to good antimicrobial activities. Further the docking study for the most active compound against DNA Gyrase was also carried out. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to Elsevier Ltd.
Keywords: Click chemistry;1,4-Disubstituted 1,2,3-triazoles; Antibacterial activity;Antifungal activity;Docking studies
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited: 14 Jul 2012 08:10
Last Modified: 14 Jul 2012 08:10
URI: http://eprints.iisc.ac.in/id/eprint/44790

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