Iron(III) Chloride-Catalysed Aerobic Reduction of Olefins using Aqueous Hydrazine at Ambient Temperature

Lamani, Manjunath and Ravikumara, Guralamata S and Prabhu, Kandikere Ramaiah (2012) Iron(III) Chloride-Catalysed Aerobic Reduction of Olefins using Aqueous Hydrazine at Ambient Temperature. In: ADVANCED SYNTHESIS & CATALYSIS, 354 (8). pp. 1437-1442.

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Abstract

A chemoselective reduction of olefins and acetylenes is demonstrated by employing catalytic amounts of ferric chloride hexahydrate (FeCl3 center dot 6H(2)O) and aqueous hydrazine (NH2NH2 center dot H2O) as hydrogen source at room temperature. The reduction is chemoselective and tolerates a variety of reducible functional groups. Unlike other metal-catalysed reduction methods, the present method employs a minimum amount of aqueous hydrazine (1.5-2 equiv.). Also, the scope of this method is demonstrated in the synthesis of ibuprofen in aqueous medium.

Item Type:	Journal Article
Publication:	ADVANCED SYNTHESIS & CATALYSIS
Publisher:	WILEY-V C H VERLAG GMBH
Additional Information:	Copyright for this article belongs to John Wiley & Sons, Inc
Keywords:	air; aqueous hydrazine;diimide;ferric chloride hexahydrate; olefins;reduction;selectivity
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	26 Jun 2012 10:29
Last Modified:	26 Jun 2012 10:29
URI:	http://eprints.iisc.ac.in/id/eprint/44744

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