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Mixed-ligand aroylhydrazone complexes of molybdenum: Synthesis, structure and biological activity

Pasayat, Sagarika and Dash, Subhashree P and Saswati, * and Majhi, Paresh Kumar and Patil, Yogesh P and Nethaji, M and Dash, Hirak R and Das, Surajit and Dinda, Rupam (2012) Mixed-ligand aroylhydrazone complexes of molybdenum: Synthesis, structure and biological activity. In: POLYHEDRON, 38 (1). pp. 198-204.

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Official URL: http://dx.doi.org/10.1016/j.poly.2012.03.007


The reaction of the benzoylhydrazone of 2-hydroxybenzaldehyde (H2L) with MoO2(acac)(2)] proceeds smoothly in refluxing ethanol to afford an orange complex MoO2L(C2H5OH)] (1). The substrate binding capacity of 1 has been demonstrated by the formation and isolation of two mononuclear MoO2L(Q)] {where Q = imidazole (2a) and 1-methylimidazole (2b)} and one dinuclear (MoO2L)(2)(Q)] {Q = 4,4'-bipyridine (3)} mixed-ligand oxomolybdenum complex. All the complexes have been characterized by elemental analysis, magnetic and spectroscopic (IR, UV-Vis and NMR) measurements. The molecular structures of all the oxomolybdenum(VI) complexes (1, 2a, 2b and 3) have been determined by X-ray crystallography. In each complex, the dianionic planar ligand is coordinated to the metal centre via one enolate oxygen, one phenolate oxygen and an azomethine nitrogen atom. The complexes have been screened for their antibacterial activity against Escherichia coli, Bacillus and Pseudomonas aeruginosa. The minimum inhibitory concentration of these complexes and their antibacterial activity indicates that compounds 2a and 2b are potential lead molecules for drug designing. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Publication: POLYHEDRON
Additional Information: Copyright for this article belongs to the Elseview
Keywords: Mixed-ligand aroylhydrazone complexes;Oxomolybdenum(VI);X-ray crystal structure;Antibacterial activity
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 07 Jul 2012 08:12
Last Modified: 07 Jul 2012 08:12
URI: http://eprints.iisc.ac.in/id/eprint/44696

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