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Typhoid fever & vaccine development: a partially answered question

Marathe, Sandhya A and Lahiri, Amit and Negi, Vidya Devi and Chakravortty, Dipshikha (2012) Typhoid fever & vaccine development: a partially answered question. In: Indian Journal of Medical Research, 135 (2). pp. 161-169.

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Typhoid fever is a systemic disease caused by the human specific Gram-negative pathogen Salmonella enterica serovar Typhi (S Typhi). The extra-intestinal infections caused by Salmonella are very fatal. The incidence of typhoid fever remains very high in impoverished areas and the emergence of multidrug resistance has made the situation worse. To combat and to reduce the morbidity and mortality caused by typhoid fever, many preventive measures and strategies have been employed, the most important being vaccination. In recent years, many Salmonella vaccines have been developed including live attenuated as well as DNA vaccines and their clinical trials have shown encouraging results. But with the increasing antibiotic resistance, the development of potent vaccine candidate for typhoid fever is a need of the hour. This review discusses the latest trends in the typhoid vaccine development and the clinical trials which are underway.

Item Type: Journal Article
Publication: Indian Journal of Medical Research
Publisher: Indian Council of Medical Research
Additional Information: Indian Journal of Medical Research
Keywords: DNA vaccine;immunity;Salmonella;typhoid fever;vaccination
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 16 Jun 2012 07:34
Last Modified: 23 Jun 2012 04:01
URI: http://eprints.iisc.ac.in/id/eprint/44613

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