Evaluation of DNA binding, antioxidant and cytotoxic activity of mononuclear Co(III) complexes of 2-oxo-1,2-dihydrobenzoh]quinoline-3-carbaldehyde thiosemicarbazones

Ramachandran, Eswaran and Thomas, Sajesh P and Poornima, Paramasivan and Kalaivani, Palaniappan and Prabhakaran, Rathinasabapathi and Padma, Viswanadha Vijaya and Natarajan, Karuppannan (2012) Evaluation of DNA binding, antioxidant and cytotoxic activity of mononuclear Co(III) complexes of 2-oxo-1,2-dihydrobenzoh]quinoline-3-carbaldehyde thiosemicarbazones. In: European Journal of Medicinal Chemistry, 50 . pp. 405-415.

PDF jou_med_che_50_405_2012.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy

Abstract

Four new 2-oxo-1,2-dihydrobenzoh]quinoline-3-carbaldehyde N-substituted thiosemicarbazone ligands (H-2-LR, where R = H, Me, Et or Ph) and their corresponding new cobalt(III) complexes have been synthesized and characterized. The structures of the complexes 2 and 3 were determined by single crystal X-ray diffraction analysis. The interactions of the new complexes with DNA were investigated by absorption, emission and viscosity studies which indicated that the complexes bind to DNA via intercalation. Antioxidant studies of the new complexes showed that the significant antioxidant activity against DPPH radical. In addition, the in vitro cytotoxicity of complexes 1-4 against A549 cell line was assayed which showed higher cytotoxic activity with lower IC50 values indicating their efficiency in killing the cancer cells even at very low concentrations. (C) 2012 Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Publication:	European Journal of Medicinal Chemistry
Publisher:	Elsevier Science
Additional Information:	Copyright of this article is belongs to Elsevier Science.
Keywords:	Cobalt(III) complexes;Benzo[h]quinoline;Thiosemicarbazones; DNA binding;Antioxidant
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	23 Aug 2012 07:50
Last Modified:	23 Aug 2012 07:52
URI:	http://eprints.iisc.ac.in/id/eprint/44475

Actions (login required)

View Item