Novel and efficient protocol for the syntheses of N-1 substituted thiohydantoin and a bicyclothiohydantoin under solvent-free conditions

Kumar, Vinod and Rana, Hemlata and Sankolli, Ravish and Kaushik, MP (2012) Novel and efficient protocol for the syntheses of N-1 substituted thiohydantoin and a bicyclothiohydantoin under solvent-free conditions. In: Tetrahedron Letters, 53 (19). pp. 2377-2379.

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Abstract

A novel approach for the synthesis of N-1 substituted thiohydantoin has been developed to give quantitative yields of the desired products. The efficient synthesis of bis-thiohydantoin derivative and bicyclothiohydantoin has extended scope and applicability of present method. Solvent-free conditions and very easy work-up procedure make the reaction convenient and eco-friendly. All the products were characterized by spectroscopic techniques and elemental analysis, and finally the structure of representative ;compound was also confirmed by X-ray crystallography. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Publication:	Tetrahedron Letters
Publisher:	Elsevier Science
Additional Information:	Copyright of this article is belongs to Elsevier Science.
Keywords:	Thiohydantoin;Methyl N-cyano-N-alkyl/arylaminoacetate; Bicyclothiohydantoin and bis-thiohydantoin; Diethylthiophosphate;Solvent-free conditions
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	21 Aug 2012 03:48
Last Modified:	21 Aug 2012 03:48
URI:	http://eprints.iisc.ac.in/id/eprint/44434

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