Ribosome-RNA interaction: a potential target for developing antiviral against hepatitis C virus

Ray, Upasana and Ray, Partho Sarothi and Das, Saumitra (2012) Ribosome-RNA interaction: a potential target for developing antiviral against hepatitis C virus. In: Current Science (Bangalore), 102 (3). pp. 405-412.

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Abstract

Hepatitis C virus (HCV), a member of Flaviviridae, encoding a positive-sense single-stranded RNA translates by cap-independent mechanism using the internal ribosome entry site (IRES) present in the 5' UTR of the virus. The IRES has complex stem loop structures and is capable of recruiting the 40S ribosomal subunit in a factor-independent fashion. As the IRES sequence is highly conserved throughout the HCV genotypes and the translation is the first obligatory step of the HCV life cycle, the IRE'S-mediated translation, or more specifically, the ribosome HCV RNA interaction is an attractive target to design effective antivirals. This article will focus on the mechanism of the HCV IRES translation and the various ways in which the interaction of ribosome and IRES has been targeted.

Item Type:	Journal Article
Publication:	Current Science (Bangalore)
Publisher:	Indian Academy of Sciences
Additional Information:	Copyright of this article belongs to Indian Academy of Sciences.
Keywords:	Antivirals;ribosomes;hepatitis C virus;replication and translation
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	13 Apr 2012 09:05
Last Modified:	13 Apr 2012 09:05
URI:	http://eprints.iisc.ac.in/id/eprint/44263

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