Molybdenum trioxide catalyzed oxidative cross-dehydrogenative coupling of benzylic sp(3) C-H bonds: synthesis of alpha-aminophosphonates under aerobic conditions

Alagiri, Kaliyamoorthy and Devadig, Pradeep and Prabhu, Kandikere R (2012) Molybdenum trioxide catalyzed oxidative cross-dehydrogenative coupling of benzylic sp(3) C-H bonds: synthesis of alpha-aminophosphonates under aerobic conditions. In: Tetrahedron Letters, 53 (12). pp. 1456-1459.

PDF Molybdenum.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy

Abstract

Molybdenum trioxide (MoO3) catalyzed efficient oxidative cross-dehydrogenative-coupling (CDC) method for C-H functionalization of N-aryl tetrahydroisoquinolines has been explored. This user-friendly method of synthesizing alpha-aminophosphonates employs 1.1 equiv of dialkyl-H-phosphonate under aerobic condition. Formation of new C-P bonds from unfunctionalized starting materials under environmentally benign conditions provides an excellent avenue for the synthesis of biologically active alpha-aminophosphonates. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Publication:	Tetrahedron Letters
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	CDC reaction;Aerobic oxidation;C-H functionalization; Molybdenum;Hydrophosphorylation
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	17 Apr 2012 11:28
Last Modified:	17 Apr 2012 11:28
URI:	http://eprints.iisc.ac.in/id/eprint/44248

Actions (login required)

View Item