Synthesis, spectroscopic properties and biological evaluation of transition metal complexes of salicylhydrazone of anthranilhydrazide: X-ray crystal structure of copper complex

Badiger, Dayananda S and Hunoor, Rekha S and Patil, Basavaraj R and Vadavi, Ramesh S and Mangannavar, Chandrashekhar V and Muchchandi, Iranna S and Patil, Yogesh P and Nethaji, Munirathinam and Gudasi, Kalagouda B (2012) Synthesis, spectroscopic properties and biological evaluation of transition metal complexes of salicylhydrazone of anthranilhydrazide: X-ray crystal structure of copper complex. In: Inorganica Chimica Acta, 384 . pp. 197-203.

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Abstract

The transition metal complexes of salicylhydrazone of anthranilhydrazide (H2L) were synthesised. The structures of metal complexes were characterized by various spectroscopic [IR, NMR, UV-Vis, EPR], thermal and other physicochemical methods. The single-crystal X-ray diffraction study of [Cu(HL)Cl]center dot H2O reveal its orthorhombic system with space group P2(1)2(1)2 and Z=4. The copper center has a distorted square planar geometry with ONO and Cl as the donor atoms. The ligand and its metal chelates have been screened for their antimicrobial and anti-tubercular activities using serial dilution method. Metal complexes in general have exhibited better antibacterial and antifungal activity than the free ligand and in few cases better than the standard used. Among the bacterial strains used, the complexes are highly potent against Gram-positive strains compared to Gram-negative. Anti-tubercular activity exhibited by the Co(II) complex is comparable with the standard used. (C) 2011 Elsevier B. V. All rights reserved.

Item Type:	Journal Article
Publication:	Inorganica Chimica Acta
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Hydrazone;Crystal structure;Metal complex;Anti-tubercular activity;Antimicrobial activity
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	17 Apr 2012 11:22
Last Modified:	17 Apr 2012 11:22
URI:	http://eprints.iisc.ac.in/id/eprint/44155

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