From anomalies in neat liquid to structure, dynamics and function in the biological world

Bagchi, Biman (2012) From anomalies in neat liquid to structure, dynamics and function in the biological world. In: Chemical Physics Letters, 529 . pp. 1-9.

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Abstract

Water brings its remarkable thermodynamic and dynamic anomalies in the pure liquid state to biological world where water molecules face a multitude of additional interactions that frustrate its hydrogen bond network. Yet the water molecules participate and control enormous number of biological processes in manners which are yet to be understood at a molecular level. We discuss thermodynamics, structure, dynamics and properties of water around proteins and DNA, along with those in reverse micelles. We discuss the roles of water in enzyme kinetics, in drug-DNA intercalation and in kinetic-proof reading ( the theory of lack of errors in biosynthesis). We also discuss how water may play an important role in the natural selection of biomolecules. (C) 2011 Elsevier B. V. All rights reserved.

Item Type:	Journal Article
Publication:	Chemical Physics Letters
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	20 Mar 2012 11:31
Last Modified:	20 Mar 2012 11:31
URI:	http://eprints.iisc.ac.in/id/eprint/44009

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