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Synthesis and DNA cleavage studies of novel quinoline oxime esters

Bindu, PJ and Mahadevan, KM and Satyanarayan, ND and Naik, Ravikumar TR (2012) Synthesis and DNA cleavage studies of novel quinoline oxime esters. In: Bioorganic & Medicinal Chemistry Letters, 22 (2). pp. 898-900.

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New 2-chloro-3-formyl quinoline oxime esters were synthesized by the reaction of 2-chloro-3-formyl quinoline oximes with various benzoyl chlorides in the presence of triethyl amine and dichloromethane at 0 degrees C. The DNA photo cleavage studies of some new oxime esters were investigated by neutral agarose gel electrophoresis at different concentrations (40 mu M and 80 mu M). Analysis of the cleavage products in agarose gel indicated that few of quinoline oxime esters (3d-i) converted into supercoiled pUC19 plasmid DNA to its nicked or linear form. (C) 2011 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Publication: Bioorganic & Medicinal Chemistry Letters
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Quinoline;Oxime ester;DNA;Photo cleavage
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 27 Feb 2012 12:20
Last Modified: 27 Feb 2012 12:20
URI: http://eprints.iisc.ac.in/id/eprint/43674

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