Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents

Thomas, KD and Adhikari, Airody Vasudeva and Telkar, Sandeep and Chowdhury, Imran H and Mahmood, Riaz and Pal, Nishith K and Row, Guru and Sumesh, E (2011) Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents. In: European Journal of Medicinal Chemistry, 46 (11). pp. 5283-5292.

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Abstract

Three new series of 4-hydroxy-8-trifluoromethyl-quinoline derivatives were synthesized through multi step reactions. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of 5j was evidenced by X-ray crystallographic study. The newly synthesized title compounds were evaluated for their antimicrobial activities including antimycobacterial activity. Amongst the tested compounds, 5b, 5e, 5h, 5j, 6c and 7c displayed promising antimicrobial activity. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands, 5b, 5e, 5h, 5j and 6c. (C) 2011 Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Publication:	European Journal of Medicinal Chemistry
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Quinoline;Antibacterial;Antimycobacterial;X-ray crystallography;Docking study
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	03 Feb 2012 12:31
Last Modified:	03 Feb 2012 12:31
URI:	http://eprints.iisc.ac.in/id/eprint/43398

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