NMRof peptides

Raghothama, S (2010) NMRof peptides. In: Journal of the Indian Institute of Science, 90 (1). pp. 145-161.

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Abstract

Developments and applications of NMR spectroscopy especially with biomolecules has taken big strides over the decades. This review gives a brief overview of peptide analysis by NMR as carried out in the author’s laboratory. A brief introduction to peptide biomolecules and NMR useful parameters are discussed in the beginning. This is followed by diagnostics features observed in NMR for identification of secondary structures. It further goes on to show how a three dimensional structure could be obtained by all-important NOE and hydrogen bond information. Use of heteronuclear experiments, which could be done at natural abundance is also highlighted in getting more details of peptide structures.Applications using Solid state NMR at natural abundance in connecting peptide solution and x-ray structures is demonstrated with couple of examples.

Item Type:	Journal Article
Publication:	Journal of the Indian Institute of Science
Publisher:	The Indian Institute of Science (IISc)
Additional Information:	Copyright of this article belongs to The Indian Institute of Science (IISc).
Department/Centre:	Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility)
Date Deposited:	09 Feb 2012 09:34
Last Modified:	09 Feb 2012 09:34
URI:	http://eprints.iisc.ac.in/id/eprint/43318

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