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Immunomodulation using agonists and antagonists: potential clinical applications

Iyer, Namrata and Marathe, Sandhya A and Chaudhuri, Debalina and Garai, Preeti and Chakravortty, Dipshikha (2012) Immunomodulation using agonists and antagonists: potential clinical applications. In: Expert Opinion on Investigational Drugs, 21 (1). pp. 67-81.

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Official URL: http://informahealthcare.com/doi/abs/10.1517/13543...


Introduction: Extensive studies have gone into understanding the differential role of the innate and adaptive arms of the immune system in the context of various diseases. Receptor-ligand interactions are responsible for mediating cross-talk between the innate and adaptive arms of the immune system, so as to effectively counter the pathogenic challenge. While TLRs remain the best studied innate immune receptor, many other receptor families are now coming to the fore for their role in various pathologies. Research has focused on the discovery of novel agonists and antagonists for these receptors as potential therapeutics. Areas covered: In this review, we present an overview of the recent advances in the discovery of drugs targeting important receptors such as G-protein coupled receptors, TRAIL-R, IL-1 beta receptor, PPARs, etc. All these receptors play a critical role in the modulation of the immune response. We focus on the recent paradigms applied for the generation of specific and effective therapeutics for these receptors and their status in clinical trials. Expert opinion: Non-specific activation by antagonist/agonist is a difficult problem to dodge. This demands innovation in ligand designing with the use of strategies such as allosterism and dual-specific ligands. Rigorous preclinical and clinical studies are required in transforming a compound to a therapeutic.

Item Type: Journal Article
Publication: Expert Opinion on Investigational Drugs
Publisher: Informa plc
Additional Information: Copyright of this article belongs to Informa plc.
Keywords: agonist;antagonist;CCR5;GCPRs;immune receptors;preclinical trials;TRAIL
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 24 Jan 2012 09:45
Last Modified: 22 Oct 2018 15:04
URI: http://eprints.iisc.ac.in/id/eprint/43144

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