Subdiffusion as a model of transport through the nuclear pore complex

Chatterjee, Debarati and Cherayil, Binny J (2011) Subdiffusion as a model of transport through the nuclear pore complex. In: Journal of Chemical Physics, The, 135 (15).

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Abstract

Cargo transport through the nuclear pore complex continues to be a subject of considerable interest to experimentalists and theorists alike. Several recent studies have revealed details of the process that have still to be fully understood, among them the apparent nonlinearity between cargo size and the pore crossing time, the skewed, asymmetric nature of the distribution of such crossing times, and the non-exponentiality in the decay profile of the dynamic autocorrelation function of cargo positions. In this paper, we show that a model of pore transport based on subdiffusive particle motion is in qualitative agreement with many of these observations. The model corresponds to a process of stochastic binding and release of the particle as it moves through the channel. It suggests that the phenylalanine-glycine repeat units that form an entangled polymer mesh across the channel may be involved in translocation, since these units have the potential to intermittently bind to hydrophobic receptor sites on the transporter protein. (C) 2011 American Institute of Physics. [doi:10.1063/1.3651100]

Item Type:	Journal Article
Publication:	Journal of Chemical Physics, The
Publisher:	American Institute of Physics
Additional Information:	Copyright of this article belongs to American Institute of Physics.
Keywords:	biochemistry;biodiffusion;hydrophobicity;molecular biophysics;polymers;proteins;stochastic processes
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	20 Dec 2011 11:54
Last Modified:	20 Dec 2011 11:54
URI:	http://eprints.iisc.ac.in/id/eprint/42782

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