Theoretical Studies on \beta -lactam Antibiotics. IV. Conformational Analysis of Novel \beta -lactam Antibiotics and the Binding Specificities of Crosslinking Enzyme(s) and \beta -lactamases

Vasudevan, TK and Rao, VSR (1981) Theoretical Studies on \beta -lactam Antibiotics. IV. Conformational Analysis of Novel \beta -lactam Antibiotics and the Binding Specificities of Crosslinking Enzyme(s) and \beta -lactamases. In: Biopolymers, 20 (5). pp. 865-877.

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Abstract

Conformational-energy calculations were carried out on the new family of \beta -lactam antibiotics (viz., thienamycin, PS-5, 1-oxa- and 1-thiapenems, and their close analogs); these exhibit broad-spectrum antibacterial activity and stability towards \beta -lactamase-producing strains. The bicyclic ring system in all the compounds studied was found to be highly rigid and to favor only one conformation. This is in contrast to findings in penicillins, where the five-membered ring assumes two puckered conformations. The relative orientations of the bicyclic ring system and the nature and configuration of the substituent at C-5 position, besides nonplanarity of the lactam peptide bond, are shown to be important for biological activity. The present study, in agreement with x-ray studies, predicts that the lactam peptide bond in 1-carbapenem is more nonplanar than in 1-thiapenem. These studies also suggest that the conformational requirement of bicyclic ring system to bind to crosslinking enzyme(s) and \beta -lactamases is very similar.

Item Type:	Journal Article
Publication:	Biopolymers
Publisher:	John Wiley & Sons, Inc.
Additional Information:	The copyright belongs to John Wiley & Sons, Inc.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	08 Dec 2005
Last Modified:	19 Sep 2010 04:21
URI:	http://eprints.iisc.ac.in/id/eprint/4278

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