Ultrasound modulated optical tomography: Young's modulus of the insonified region from measurement of natural frequency of vibration

Chandran, Sriram R and Roy, Debasish and Kanhirodan, Rajan and Vasu, Ram Mohan and Devi, Usha C (2011) Ultrasound modulated optical tomography: Young's modulus of the insonified region from measurement of natural frequency of vibration. In: Optics Express, 19 (23). pp. 22837-22850.

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Abstract

We demonstrate a method to recover the Young's modulus (E) of a tissue-mimicking phantom from measurements of ultrasound modulated optical tomography (UMOT). The object is insonified by a dualbeam, confocal ultrasound transducer (US) oscillating at frequencies f(0) and f(0) + Delta f and the variation of modulation depth (M) in the autocorrelation of light traversed through the focal region of the US transducer against Delta f is measured. From the dominant peaks observed in the above variation, the natural frequencies of the insonified region associated with the vibration along the US transducer axis are deduced. A consequence of the above resonance is that the speckle fluctuation at the resonance frequency has a higher signal-to-noise to ratio (SNR). From these natural frequencies and the associated eigenspectrum of the oscillating object, Young's modulus (E) of the material in the focal region is recovered. The working of this method is confirmed by recovering E in the case of three tissue-mimicking phantoms of different elastic modulus values. (C) 2011 Optical Society of America

Item Type:	Journal Article
Publication:	Optics Express
Publisher:	Optical Soc Amer
Additional Information:	Copyright of this article belongs to Optical Soc Amer.
Department/Centre:	Division of Mechanical Sciences > Civil Engineering Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics
Date Deposited:	21 Dec 2011 09:22
Last Modified:	21 Dec 2011 09:22
URI:	http://eprints.iisc.ac.in/id/eprint/42611

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