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Base excision and nucleotide excision repair pathways in mycobacteria

Kurthkoti, Krishna and Varshney, Umesh (2011) Base excision and nucleotide excision repair pathways in mycobacteria. In: Tuberculosis, 91 (6). pp. 533-543.

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Official URL: http://dx.doi.org/10.1016/j.tube.2011.06.005


About a third of the human population is estimated to be infected with Mycobacterium tuberculosis. The bacterium displays an excellent adaptability to survive within the host macrophages. As the reactive environment of macrophages is capable of inducing DNA damage, the ability of the pathogen to safeguard its DNA against the damage is of paramount significance for its survival within the host. Analysis of the genome sequence has provided important insights into the DNA repair machinery of the pathogen, and the studies on DNA repair in mycobacteria have gained momentum in the past few years. The studies have revealed considerable differences in the mycobacterial DNA repair machinery when compared with those of the other bacteria. This review article focuses especially on the aspects of base excision, and nucleotide excision repair pathways in mycobacteria. (C) 2011 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Publication: Tuberculosis
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Hypoxia;BER;NER;Ung;UdgB
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 07 Dec 2011 06:41
Last Modified: 07 Dec 2011 06:41
URI: http://eprints.iisc.ac.in/id/eprint/42529

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