Kumar, Vinod and Rana, Hemlata and Sankolli, Ravish and Kaushik, MP (2011) Highly efficient dialkylphosphate-mediated syntheses of hydantoins and a bicyclohydantoin under solvent-free conditions. In: Tetrahedron Letters, 52 (46). pp. 6148-6151.
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Abstract
Diversely substituted hydantoins have been synthesized by new strategy from cyanamide based precursor, that is, methyl N-cyano-N-alkyl/arylaminoacetate. Dialkylphosphates were employed as the mild reagent to hydrolyze and cyclize the substrate in one step to give quantitative yields of the desired products. Syntheses of multivalent hydantoins viz bis-hydantoin, bicyclohydantoin have potentially widened the scope and applicability of the present method. Solvent-free conditions and very easy work-up procedure make the reaction convenient and eco-friendly. Single crystal structures of some of the representative compounds are also reported. (C) 2011 Elsevier Ltd. All rights reserved.
Item Type: | Journal Article |
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Publication: | Tetrahedron Letters |
Publisher: | Elsevier Science |
Additional Information: | Copyright of this article belongs to Elsevier Science. |
Keywords: | Methyl N-cyano-N-alkyl/arylaminoacetate;Hydantoin and bicyclohydantoin;Hydrolysis and cyclization; Dialkylphosphate;Solvent-free conditions |
Department/Centre: | Division of Chemical Sciences > Solid State & Structural Chemistry Unit |
Date Deposited: | 07 Dec 2011 06:31 |
Last Modified: | 07 Dec 2011 06:31 |
URI: | http://eprints.iisc.ac.in/id/eprint/42523 |
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