Angiotensin converting enzyme inhibitors in the treatment of hypertension

Bhuyan, Bhaskar J and Mugesh, Govindasamy (2011) Angiotensin converting enzyme inhibitors in the treatment of hypertension. In: Current Science (Bangalore), 101 (7). pp. 881-887.

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Abstract

Angiotensin converting enzyme (ACE) catalyses the conversion of angiotensin I (Ang I) to angiotensin II (Ang II). The ACE activity directly related to hypertension as Ang II is the blood pressure regulating hormone. Therefore, ACE inhibitors are a major class of antihypertensive drugs. Captopril, chemical name, was the first orally active ACE inhibitory antihypertensive drug, discovered in 1977. Since then, a number of such drugs have been synthesized. Enzyme-inhibitor bound crystal structural studies reveal a great deal of understanding about the interactions of the inhibitors at the active site of ACE. This can be helpful in the rational design of ACE inhibitors. With the advancement of the combination therapy, it is known that ACE inhibitors having antioxidant activity can be beneficial for the treatment of hypertension. This study describes the development of ACE inhibitors in the treatment of hypertension. Importance of ACE inhibitors having antioxidant activity is also described.

Item Type:	Journal Article
Publication:	Current Science (Bangalore)
Publisher:	Indian Academy of Sciences
Additional Information:	Copyright of this article belongs to Indian Academy of Sciences.
Keywords:	Angiotensin converting enzyme;angiotensinogen;hypertension; rennin angiotensin system
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	28 Nov 2011 11:58
Last Modified:	28 Nov 2011 11:58
URI:	http://eprints.iisc.ac.in/id/eprint/42424

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