Clinical Proteomics of the Neglected Human Malarial Parasite Plasmodium vivax

Acharya, Pragyan and Pallavi, Rani and Chandran, Syama and Dandavate, Vrushali and Sayeed, Syed Khund and Rochani, Ankit and Acharya, Jyoti and Middha, Sheetal and Kochar, Sanjay and Kochar, Dhanpat and Ghosh, Susanta Kumar and Tatu, Utpal (2011) Clinical Proteomics of the Neglected Human Malarial Parasite Plasmodium vivax. In: PLos One, 6 (10).

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Abstract

Recent reports highlight the severity and the morbidity of disease caused by the long neglected malaria parasite Plasmodium vivax. Due to inherent difficulties in the laboratory-propagation of P. vivax, the biology of this parasite has not been adequately explored. While the proteome of P. falciparum, the causative agent of cerebral malaria, has been extensively explored from several sources, there is limited information on the proteome of P. vivax. We have, for the first time, examined the proteome of P. vivax isolated directly from patients without adaptation to laboratory conditions. We have identified 153 proteins from clinical P. vivax, majority of which do not show homology to any previously known gene products. We also report 29 new proteins that were found to be expressed in P. vivax for the first time. In addition, several proteins previously implicated as anti-malarial targets, were also found in our analysis. Most importantly, we found several unique proteins expressed by P. vivax. This study is an important step in providing insight into physiology of the parasite under clinical settings.

Item Type:	Journal Article
Publication:	PLos One
Publisher:	Public Library of Science
Additional Information:	Copyright of this article belongs to Public Library of Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	28 Nov 2011 11:54
Last Modified:	23 Feb 2012 07:26
URI:	http://eprints.iisc.ac.in/id/eprint/42418

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