Molecular profile of oligodendrogliomas in young patients

Sun, Vaishali and Jha, Prerana and Agarwal, Shipra and Pathak, Pankaj and Sharma, Mehar Chand and Sharma, Vikas and Shukla, Sudhanshu and Somasundaram, Kumaravel and Mahapatra, Ashok Kumar and Kale, Shashank Sharad and Sarkar, Chitra (2011) Molecular profile of oligodendrogliomas in young patients. In: Neuro-Oncology, 13 (10). pp. 1099-1106.

PDF Neuro_oncology_2011.pdf - Published Version Restricted to Registered users only Download (161kB) | Request a copy

Abstract

Several studies on molecular profiling of oligodendrogliomas (OGs) in adults have shown a distinctive genetic pattern characterized by combined deletions of chromosome arms 1 p and 19q, O6-methylguanine-methyltransferase (MGMT) methylation, and isocitrate dehydrogenase 1 (IDH1) mutation, which have potential diagnostic, prognostic, and even therapeutic relevance. OGs in pediatric and young adult patients are rare and have been poorly characterized on a molecular and biological basis, and it remains uncertain whether markers with prognostic significance in adults also have predictive value in these patients. Fourteen cases of OGs in young patients (age, <= 25 years) who received a diagnosis over 7 years were selected (7 pediatric patients age <= 18 years and 7 young adults aged 19-25 years). The cases were evaluated for 1p/19q status, MGMT promoter methylation, p53 mutation, and IDH1 mutation. None of the pediatric cases showed 1p/19q deletion. In young adults, combined 1p/19q loss was observed in 57% and isolated 1p loss in 14% of cases. The majority of cases in both subgroups (71% in each) harbored MGMT gene promoter methylation. TP53 and IDH1 mutations were not seen in any of the cases in both the groups. To our knowledge, this is the first study to show that molecular profile of OGs in pediatric and young adult patients is distinct. Further large-scale studies are required to identify additional clinically relevant genetic alterations in this group of patients.

Item Type:	Journal Article
Publication:	Neuro-Oncology
Publisher:	Duke University Press
Additional Information:	Copyright of this article belongs to Duke University Press.
Keywords:	adolescent;IDH1;MGMT;oligodendrogliomas;1p/19q;pediatric; p53;TP53;young adults
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	24 Nov 2011 06:08
Last Modified:	24 Nov 2011 08:37
URI:	http://eprints.iisc.ac.in/id/eprint/42293

Actions (login required)

View Item