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Development of vaccines against tuberculosis

Tyagi, Anil K. and Nangpal, Prachi and Satchidanandam, Vijaya (2011) Development of vaccines against tuberculosis. In: Tuberculosis, 91 (5, SI). pp. 469-478.

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Official URL: http://dx.doi.org/10.1016/j.tube.2011.01.003


Development of an effective vaccine against tuberculosis (TB) hinges on an improved understanding of the human immune responses to Mycobacterium tuberculosis. A successful vaccination strategy should be able to stimulate the appropriate arm of the immune system with concomitant generation of the memory cells. In the absence of a perfect strategy, while long term efforts of TB researchers continue to resolve the nature of protective immunity against TB and other related issues, the current approach, dictated by the urgency of a TB vaccine, employs available knowledge and technology to develop new TB vaccines and channel the promising ones to clinical trials. While Indian scientists have contributed in several areas towards the development of a TB vaccine, this review is an attempt to summarize their contributions mainly pertaining to the discovery of new antigens, immune responses elicited by antigens against TB and development of new vaccines and their evaluation in animal models. (C) 2011 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Publication: Tuberculosis
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Mycobacteria;Tuberculosis;Vaccines;Immune responses
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 03 Nov 2011 11:21
Last Modified: 03 Nov 2011 11:21
URI: http://eprints.iisc.ac.in/id/eprint/41656

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