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Signalling mechanisms in Mycobacteria

Chakraborti, Pradip K and Matange, Nishad and Nandicoori, Vinay K and Singh, Yogendra and Tyagi, Jaya S and Visweswariah, Sandhya S (2011) Signalling mechanisms in Mycobacteria. In: Tuberculosis, 91 (5, SI). pp. 432-440.

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Official URL: http://dx.doi.org/10.1016/j.tube.2011.04.005


The importance of inter-and intracellular signal transduction in all forms of life cannot be underestimated. A large number of genes dedicated to cellular signalling are found in almost all sequenced genomes, and Mycobacteria are no exception. What appears to be interesting in Mycobacteria is that well characterized signalling mechanisms used by bacteria, such as the histidine-aspartate phosphorelay seen in two-component systems, are found alongside signalling components that closely mimic those seen in higher eukaryotes. This review will describe the important contribution made by researchers in India towards the identification and characterization of proteins involved in two-component signalling, protein phosphorylation and cyclic nucleotide metabolism. (C) 2011 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Publication: Tuberculosis
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Cyclic AMP;DevR;DevS;Protein kinase;Phosphodiesterase
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 03 Nov 2011 11:18
Last Modified: 03 Nov 2011 11:18
URI: http://eprints.iisc.ac.in/id/eprint/41652

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