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Simulation of RNA silencing pathway for time-dependent transgene transcription rate

Yang, Xiao-Dong and Roy Mahapatra, Debiprosad and Melnik, Roderick VN (2007) Simulation of RNA silencing pathway for time-dependent transgene transcription rate. In: AIP Conf. Proc., 952.

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The synthesis of dsRNA is analyzed using a pathway model with amplifications caused by the aberrant RNAs. The transgene influx rate is assumed time-decaying considering the fact that the number of transgenes can not be infinite. The dynamics of the transgene induced RNA silencing is investigated using a system of coupled nonautonomous ordinary nonlinear differential equations which describe the model phenomenologically. The silencing phenomena are detected after a period of transcription. Important contributions of certain parameters are discussed with several numerical examples.

Item Type: Conference Paper
Publisher: American Institute of Physics
Additional Information: Copyright of this article belongs to American Institute of Physics.
Keywords: macromolecules;computer aided analysis;nonlinear differential equations
Department/Centre: Division of Mechanical Sciences > Aerospace Engineering(Formerly Aeronautical Engineering)
Date Deposited: 22 Oct 2011 07:34
Last Modified: 22 Oct 2011 07:34
URI: http://eprints.iisc.ac.in/id/eprint/41595

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