Yang, Xiao-Dong and Roy Mahapatra, Debiprosad and Melnik, Roderick VN (2007) Simulation of RNA silencing pathway for time-dependent transgene transcription rate. In: AIP Conf. Proc., 952.
Full text not available from this repository. (Request a copy)Abstract
The synthesis of dsRNA is analyzed using a pathway model with amplifications caused by the aberrant RNAs. The transgene influx rate is assumed time-decaying considering the fact that the number of transgenes can not be infinite. The dynamics of the transgene induced RNA silencing is investigated using a system of coupled nonautonomous ordinary nonlinear differential equations which describe the model phenomenologically. The silencing phenomena are detected after a period of transcription. Important contributions of certain parameters are discussed with several numerical examples.
| Item Type: | Conference Paper |
|---|---|
| Publisher: | American Institute of Physics |
| Additional Information: | Copyright of this article belongs to American Institute of Physics. |
| Keywords: | macromolecules;computer aided analysis;nonlinear differential equations |
| Department/Centre: | Division of Mechanical Sciences > Aerospace Engineering(Formerly Aeronautical Engineering) |
| Date Deposited: | 22 Oct 2011 07:34 |
| Last Modified: | 22 Oct 2011 07:34 |
| URI: | http://eprints.iisc.ac.in/id/eprint/41595 |
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