Enantioselective total synthesis of (−)-epoxyquinols A and B. Novel, convenient access to chiral epoxyquinone building blocks through enzymatic desymmetrization

Mehta, Goverdhan and Islam, Kabirul (2004) Enantioselective total synthesis of (−)-epoxyquinols A and B. Novel, convenient access to chiral epoxyquinone building blocks through enzymatic desymmetrization. In: Tetrahedron Letters, 45 (18). pp. 3611-3615.

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Abstract

Following our recent total synthesis of the biologically potent natural products epoxyquinols A and B in racemic form, we have now accomplished the total synthesis of the (−)-epoxyquinols A and B, anti-podes of the angiogenesis inhibiting natural products, through a protocol that involves enzymatic desymmetrization of a versatile epoxyquinone derivative, readily available from the Diels–Alder adduct of cyclopentadiene and p-benzoquinone.

Item Type:	Journal Article
Publication:	Tetrahedron Letters
Publisher:	Elsevier Science Ltd.
Additional Information:	Copyright for this article belongs to Elsevier Science Ltd.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	21 Jun 2004
Last Modified:	19 Sep 2010 04:12
URI:	http://eprints.iisc.ac.in/id/eprint/410

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