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Beta-structure of polypeptides in non-aqueous solutions. II. Side-chain orientation

Raghavendra, K and Ananthanarayanan, VS (1981) Beta-structure of polypeptides in non-aqueous solutions. II. Side-chain orientation. In: International Journal of Peptide & Protein Research, 17 (4). pp. 420-425.

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The specific side-chain orientations of the phenyl group in the polypeptides poly-S-benzyl-L-cysteine, poly-S-carbobenzoxy-L-cysteine and poly-O-carbobenzoxy-L-serine in the beta-structure have been studied by spectral measurements in solutions. All the three polypeptides exhibit aromatic CD bands, indicating the asymmetric placement of the side-chain phenyl rings when the polypeptide backbone takes up the antiparallel beta-structure. Supporting evidence for this is derived from n.m.r. spectra of the polypeptides, which show upfield shift of the phenyl protons due to the stacking of the aromatic rings. Molecular model building studies reveal the stacking of alternate phenyl groups along the polypeptide chain.

Item Type: Journal Article
Publication: International Journal of Peptide & Protein Research
Publisher: Munksgaard Int Publ Ltd
Additional Information: Copyright of this article belongs to Munksgaard Int Publ Ltd.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 09 Nov 2011 05:23
Last Modified: 09 Nov 2011 05:23
URI: http://eprints.iisc.ac.in/id/eprint/40755

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