Reddy, Damodara N and Thirupathi, Ravula and Prabhakaran, Erode N (2011) Accessing the disallowed conformations of peptides employing amide-to-imidate modification. In: Chemical Communications, 47 (33). pp. 9417-9419.
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Abstract
Selective modification of the C-terminal amide in peptides to dihydrooxazine (a novel stable imidate isostere) by intramolecular nucleophilic cyclo-O-alkylation of the corresponding N-(3-bromopropyl)amides results in constraining of the C-terminal residue in natively disallowed conformations both in crystals and in solution.
| Item Type: | Journal Article |
|---|---|
| Publication: | Chemical Communications |
| Publisher: | Royal Society of Chemistry |
| Additional Information: | Copyright of this article belongs to Royal Society of Chemistry. |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry Division of Chemical Sciences > Solid State & Structural Chemistry Unit |
| Date Deposited: | 16 Sep 2011 09:11 |
| Last Modified: | 16 Sep 2011 09:11 |
| URI: | http://eprints.iisc.ac.in/id/eprint/40563 |
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