Reddy, Damodara N and Thirupathi, Ravula and Prabhakaran, Erode N (2011) Accessing the disallowed conformations of peptides employing amide-to-imidate modification. In: Chemical Communications, 47 (33). pp. 9417-9419.
![]() |
PDF
Accessing_the.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy |
Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2011...
Abstract
Selective modification of the C-terminal amide in peptides to dihydrooxazine (a novel stable imidate isostere) by intramolecular nucleophilic cyclo-O-alkylation of the corresponding N-(3-bromopropyl)amides results in constraining of the C-terminal residue in natively disallowed conformations both in crystals and in solution.
Item Type: | Journal Article |
---|---|
Publication: | Chemical Communications |
Publisher: | Royal Society of Chemistry |
Additional Information: | Copyright of this article belongs to Royal Society of Chemistry. |
Department/Centre: | Division of Chemical Sciences > Organic Chemistry Division of Chemical Sciences > Solid State & Structural Chemistry Unit |
Date Deposited: | 16 Sep 2011 09:11 |
Last Modified: | 16 Sep 2011 09:11 |
URI: | http://eprints.iisc.ac.in/id/eprint/40563 |
Actions (login required)
![]() |
View Item |