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How does DNA break during chromosomal translocations?

Nambiar, Mridula and Raghavan, Sathees C (2011) How does DNA break during chromosomal translocations? In: Nucleic Acids Research, 39 (14). pp. 5813-5825.

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Official URL: http://nar.oxfordjournals.org/content/39/14/5813


Chromosomal translocations are one of the most common types of genetic rearrangements and are molecular signatures for many types of cancers. They are considered as primary causes for cancers, especially lymphoma and leukemia. Although many translocations have been reported in the last four decades, the mechanism by which chromosomes break during a translocation remains largely unknown. In this review, we summarize recent advances made in understanding the molecular mechanism of chromosomal translocations.

Item Type: Journal Article
Publication: Nucleic Acids Research
Publisher: Oxford University Press
Additional Information: Copyright of this article belongs to Oxford University Press.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 15 Sep 2011 10:59
Last Modified: 15 Sep 2011 10:59
URI: http://eprints.iisc.ac.in/id/eprint/40456

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