Enantioselective total synthesis of the polyketide natural product (−)-EI-1941-2: a novel interleukin-1\beta converting enzyme (ICE) inhibitor

Mehta, Goverdhan and Roy, Subhrangsu (2005) Enantioselective total synthesis of the polyketide natural product (−)-EI-1941-2: a novel interleukin-1\beta converting enzyme (ICE) inhibitor. In: Tetrahedron Letters, 46 (46). pp. 7927-7930.

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Abstract

An enantioselective total synthesis of the novel bioactive epoxyquinone natural product (−)-EI-1941-2, exhibiting promising ICE inhibiting activity, has been accomplished from a readily available chiron derived from the Diels–Alder adduct of cyclopentadiene and p-benzoquinone.

Item Type:	Journal Article
Publication:	Tetrahedron Letters
Publisher:	Elsevier Science Ltd
Additional Information:	Copyright for this article belongs to Elsevier.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	17 Nov 2005
Last Modified:	19 Sep 2010 04:21
URI:	http://eprints.iisc.ac.in/id/eprint/4026

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