Acylation of Grignard reagents mediated by N-methylpyrrolidone: A remarkable selectivity for the synthesis of ketones

Gowda, Maravanhalli Sidde and Pande, Sushanth Sudhir and Ramakrishna, Ramesha Andagar and Prabhu, Kandikere Ramaiah (2011) Acylation of Grignard reagents mediated by N-methylpyrrolidone: A remarkable selectivity for the synthesis of ketones. In: Organic and Biomolecular Chemistry, 9 (15). pp. 5365-5368.

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Abstract

An efficient user-friendly method of acylation of Grignard reagents to selectively synthesize ketones is presented, which is assisted by simple amides such as NMP, or DMF. The present chemoselective method tolerates a variety of functional groups such as ketone, ester, nitrile and other functional groups.

Item Type:	Journal Article
Publication:	Organic and Biomolecular Chemistry
Publisher:	Royal Society of Chemistry
Additional Information:	Copyright of this article belongs to Royal Society of Chemistry.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	04 Aug 2011 11:05
Last Modified:	04 Aug 2011 11:05
URI:	http://eprints.iisc.ac.in/id/eprint/39746

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