DNA recognition by the first tail-to-tail linked distamycin-like oligopeptide dimers

Bhattacharya, S and Thomas, M (2001) DNA recognition by the first tail-to-tail linked distamycin-like oligopeptide dimers. In: Chemical Communications (16). pp. 1464-1465.

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Abstract

Sequence-specific bidentate binding to double-stranded (ds)-DNA by 'tail-to-tail' linked dimeric, distamycin analogues is described; compared to their monomeric analogues, these dimers exhibit greater affinity and longer binding site size and open up a novel avenue in the design of minor groove binders that overcome the phasing problem.

Item Type:	Journal Article
Publication:	Chemical Communications
Publisher:	Royal Society of Chemistry
Additional Information:	Copyright of this article belongs to Royal Society of Chemistry.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	02 Aug 2011 06:54
Last Modified:	02 Aug 2011 06:54
URI:	http://eprints.iisc.ac.in/id/eprint/39530

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