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Molecular mimicry by antiidiotypic monoclonal antibody to gonadotropin releasing hormone

Rajeshwari, K and Karande, AA (1999) Molecular mimicry by antiidiotypic monoclonal antibody to gonadotropin releasing hormone. In: Immunological Investigations, 28 (2-3). pp. 103-114.

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Official URL: http://informahealthcare.com/doi/abs/10.3109/08820...


Antipeptide and antiidiotypic antibodies to several receptors are known to mimic their respective ligands in transducing signals on binding their receptors. In our attempts to study gonadotropin releasing hormone receptor, antipeptide and antiidiotypic monoclonal antibodies specific to the receptor were established earlier. The antipeptide mAb F1G4 was to a synthetic peptide corresponding to the extracellular domain of human GnRH receptor and the antiidiotypic mAb 4D10C1 was to the idiotype of a GnRH specific mAb. Here we report the physiological effects of the two mAbs on binding the receptor, as investigated using in vitro cultures of(a) human term placental villi and (b) rat pituitaries. The mAb 4D10C1 exerted a dose-dependent release of human chorionic gonadonopin in cultures of human term placental villi as well as luteinising and follicle stimulating hormones in cultures of rat pituitaries.

Item Type: Journal Article
Publication: Immunological Investigations
Publisher: Informa plc
Additional Information: Copyright of this article belongs to Informa plc.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 30 Jun 2011 10:30
Last Modified: 30 Jun 2011 10:30
URI: http://eprints.iisc.ac.in/id/eprint/38677

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