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DNA binding properties of some cationic acridine derivatives

Bhattacharya, S and Thomas, M (1998) DNA binding properties of some cationic acridine derivatives. In: Journal of the Indian Chemical Society, 75 (10-12). pp. 716-724.

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Four cationic acridine derivatives have been synthesized. The positively charged amine residue in one of these is connected directly on to the acridine nucleus and in three other acridines, the amines are connected via a 9-CH2 unit to acridine. We have investigated the binding of these acridines with mammalian DNA by absorption titration, UV- and induced-CD spectroscopy and competitive ethidium bromide displacement fluorescence assay. The effects on the DNA duplex denaturation melting temperatures upon binding of each one of these are also examined. The results obtained herein clearly show that the introduction of a -CH2 group in the im mediate vicinity of the interrelation moiety introduces alterations in the DNA binding characteristics of the resulting acridines.

Item Type: Journal Article
Publication: Journal of the Indian Chemical Society
Publisher: Indian Chemical Society
Additional Information: Copyright of this article belongs to Indian Chemical Society.
Keywords: Minor-Groove;Nucleic-Acids;Duplex Dna;Cleavage;Ligands; Complexes;Design;Water;Drugs.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 09 Jun 2011 07:40
Last Modified: 09 Jun 2011 07:40
URI: http://eprints.iisc.ac.in/id/eprint/38084

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