A total synthesis of 11-O-methyldebenzoyltashironin

Mehta, Goverdhan and Maity, Pulakesh (2011) A total synthesis of 11-O-methyldebenzoyltashironin. In: Tetrahedron Letters, 52 (15). pp. 1749-1752.

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Abstract

A concise total synthesis of 11-O-methyldebenzoyltashironin is reported in which oxidative dearomatization-IMDA-RCM triad constitutes the key ring forming steps, while an unorthodox DIBAL-H mediated stereo- and regioselective reductive epoxide openings and implementation of the vinyl bromide-carbonyl equivalency concept were pivotal to the success of this endeavor. (C) 2011 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Publication:	Tetrahedron Letters
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Natural products;Neurotrophic agents;Oxidative dearomatization;Intramolecular Diels-Alder reaction;Ring closing metathesis
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	20 May 2011 06:36
Last Modified:	20 May 2011 06:36
URI:	http://eprints.iisc.ac.in/id/eprint/37671

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